Resveratrol in Combination Therapy: Mechanisms and Limitations of Resveratrol in Cancer, Regeneration, and Chronic Disease

Noori, Effat; Rezaei, Ramazan; Valiyari, Samira; Rekabgardan, Mahmood; Mohammadi, Parvin; Soleymani, Fatemeh; Sharif, Elham; Jafari, Zohreh; Rezaee, Delsuz; Hajighasemi, Fatemeh; Shams*, Forough

doi:10.61882/ibj.5210

Volume 30, Issue 3 And 2 (4-2026) IBJ 2026, 30(3 And 2): 97-124 | Back to browse issues page

‎ 10.61882/ibj.5210

PMID: 42391634

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Noori E, Rezaei R, Valiyari S, Rekabgardan M, Mohammadi P, Soleymani F, et al . Resveratrol in Combination Therapy: Mechanisms and Limitations of Resveratrol in Cancer, Regeneration, and Chronic Disease. IBJ 2026; 30 (3 and 2) :97-124
URL: http://ibj.pasteur.ac.ir/article-1-5210-en.html

Resveratrol in Combination Therapy: Mechanisms and Limitations of Resveratrol in Cancer, Regeneration, and Chronic Disease

Effat Noori ^*

, Ramazan Rezaei

, Samira Valiyari

, Mahmood Rekabgardan

, Fatemeh Hajighasemi

, Forough Shams*

Abstract:

Resveratrol (RSV), a nonflavonoid polyphenol phytoalexin, has considerable therapeutic potential for managing chronic and acute diseases due to its anti-inflammatory, anti-cancer, antimicrobial, and antioxidant properties. It can help protect cells from free radical damage and modulate signaling pathways in the body to promote overall health. RSV can also facilitate the therapeutic effects of mesenchymal stem cells by increasing their self-renewal, survival, anti-aging effects, and lineage commitment. However, the natural form of RSV has limitations, such as poor intestinal absorption and low bioavailability. This review focuses on the potential of RSV to explore its effects and mechanisms of action in cancer, regenerative medicine, and chronic disease. It also discusses how RSV can protect normal tissue against genomic instability and presents findings from combination therapies involving RSV and nanoparticle-based agents. Overall, this review highlights the latest developments regarding RSV as a promising compound, emphasizing the potential to overcome its limitations.

Keywords: Nanoparticles, Regenerative medicine, Resveratrol

Full-Text [PDF 1185 kb]

Type of Study: Review Article | Subject: Tissue Engineering and Cell Biology

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