en Tissue Engineering and Cell Biology Tissue Engineering and Cell Biology مقاله مروری Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:10.5pt"><span style="line-height:115%">Resveratrol (RSV), a nonflavonoid polyphenol phytoalexin, has considerable therapeutic potential for managing chronic and acute diseases due to its anti-inflammatory, anti-cancer, antimicrobial, and antioxidant properties. It can help protect cells from free radical damage and modulate signaling pathways in the body to promote overall health.&nbsp; RSV can also facilitate the therapeutic effects of mesenchymal stem cells by increasing their self-renewal, survival, anti-aging effects, and lineage commitment. However, the natural form of RSV has limitations, such as poor intestinal absorption and low bioavailability. This review focuses on the potential of RSV to explore its effects and mechanisms of action in cancer, regenerative medicine, and chronic disease. It also discusses how RSV can protect normal tissue against genomic instability and presents findings from combination therapies involving RSV and nanoparticle-based agents. Overall, this review&nbsp;highlights the latest developments regarding RSV as a promising&nbsp;compound, emphasizing the potential to overcome its limitations.</span></span></span></div> Nanoparticles, Regenerative medicine, Resveratrol 97 124 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6430-1&slc_lang=en&sid=1 Effat Noori effat.noori@yahoo.com 0000-0002-5274-4234 Yes Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran Ramazan Rezaei R.rezaei@shahed.ac.ir 0000-0002-4504-7238 No Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran Samira Valiyari samiravaliyari@yahoo.com 0000-0001-8270-2871 No Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran Mahmood Rekabgardan m.rekabgardan@gmail.com 0000-0002-0670-8021 No Department of Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Parvin Mohammadi pmohammadi069@gmail.com 0000-0002-4724-8113 No Department of Medical Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Fatemeh Soleymani 0009-0003-7081-2899 No Elham Sharif elhamsharifpharmd@gmail.com 0000-0001-5559-2048 No Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Zohreh Jafari Zohrehjafari2021@gmail.com 0000-0002-1532-576X No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Delsuz Rezaee rezaeedelsuz@yahoo.com 0000-0001-9547-3211 No Department of Genetic and Molecular Medicine, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran Fatemeh Hajighasemi fatimahajighasemi@gmail.com 0000-0003-0145-4621 No Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran Forough Shams* Forough.shamss@gmail.com 0000-0001-5862-2679 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran