Immediate Effect of Plasma Spark Technology on Wrinkles

Authors
Aida Sane Hoghough 1
Mohammad Ali Nilforoushzadeh 2
Mohammadreza Khani 1
Mohammad Amir Amirkhani 2
Babak Shokri 1
Pantea Bozorg Savoji 2
Erfan Ghasemi 1
Alireza Jafarzadeh 3
Alireza Dasdar 1
1 Laser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran
2 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Dermatology, Hazrat Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract
Introduction: Since the 2000s, researchers have studied the biological effects of reactive oxygen and nitrogen species generated by plasma on fibroblasts and collagen, particularly using plasma jet or Dielectric Barrier Discharge [1,2]. This research aimed to examine the effects of applying a plasma spark to reduce facial wrinkles.

Materials and Methods: A plasma spark device, manufactured by Plsma Fanavar Jam Company, was used for the treatment, and images were captured with a Visio face camera. Skin moisture, elasticity, and thickness of skin were measured using sonography and a multi-probe adaptor system. Patients signed an informed consent form, and their photographs were taken before applying a topical anesthetic oinment. After 30 minutes, the treatment was performed on the lateral canthal and naolabial lines using a dotting technique, along the length of the wrinkles. Post-treatment photographs and measurments were repeated immediately and at two-week intervals for a total of three follow-up sessions.

Results and Discussion: Plasma treatment reduced the thickness of the eyelid and nasolabial lines, measuring 20.81% and 22.29%, respectively. Additionally, changes in density were noted at 43.94% for eyelids and 35.6% for nasolabial lines, as measured by sonography. Colorimetry results showed improvements of 4.5% and 15.9% for both regions. These findings suggest that reactive oxygen species and heat have interacted with and influenced fibroblasts and collagen.

Conclusion: This study indicates that plasma treatment can help reduce wrinkles and improve skin smoothness over time, although an inflammatory response was observed immediately post-treatment.
Keywords
Face
Fibroblasts
Plasma
Rejuvenation
Spark
Iranian Biomedical Journal
Volume 30, Issue 2 - Serial Number 123
January and February 2026
Pages 32-32