Background: Traumatic brain injury or TBI can underlie epilepsy. Prevention of PTE has been of great interest to scientists. Given the antiepileptic, antioxidant and anti-inflammatory activities of curcumin, we examined whether this compound can affect epileptogenesis in rats after TBI.
Methods: Curcumin was injected once a day for two weeks. TBI was induced in the temporal cortex of anesthetized rats using a controlled cortical impact device. One day after TBI, pentylenetetrazole (PTZ), 35 mg/kg, was injected i.p. every other day until manifestation of generalized seizures. The number of PTZ injections was then recorded. Moreover, the extent of cortical and hippocampal IL-1β and glial fibrillary acidic protein (GFAP) expression in the epileptic rats were measured by Western blot analysis.
Results: Curcumin 50 and 150 mg/kg prevented the development of kindling, whereas TBI accelerated the rate of kindling. Curcumin 20 mg/kg prohibited kindling facilitation by TBI, and reduced the expression of IL-1β and GFAP induced by TBI.
Conclusion: Curcumin can stop the acceleration of epileptogenesis after TBI in rats. Inhibiting hippocampal and cortical overexpression of IL-1β and GFAP seems to be involved in this activity.
Jahi, H., Eslami, M., Sayyah*, M., Karimzadeh, F. & Alesheikh, M. (2024). Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury. Iranian Biomedical Journal, 28(Issue 2 & 3), 113–119. https://doi.org/10.61186/ibj.3978
MLA
Jahi, H., Eslami, M., Sayyah*, M., Karimzadeh, F., & Alesheikh, M. "Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury", Iranian Biomedical Journal, 28, Issue 2 & 3, 2024, 113–119. doi: 10.61186/ibj.3978
HARVARD
Jahi, H., Eslami, M., Sayyah*, M., Karimzadeh, F., & Alesheikh, M. (2024). 'Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury', Iranian Biomedical Journal, 28(Issue 2 & 3), pp. 113–119. doi: 10.61186/ibj.3978
CHICAGO
Jahi, H., Eslami, M., Sayyah*, M., Karimzadeh, F. & Alesheikh, M., "Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury." Iranian Biomedical Journal, 28 Issue 2 & 3 (2024): 113–119, doi: 10.61186/ibj.3978
VANCOUVER
Jahi H., Eslami M., Sayyah* M., Karimzadeh F., Alesheikh M. Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury. Iranian Biomedical Journal. 2024;28(Issue 2 & 3):113–119. doi: 10.61186/ibj.3978
