Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury

Voronkov, Nikita S.; Popov, Sergey V.; Naryzhnaya, Natalia V.; Prasad, N. Rajendra; Petrov, Ivan M.; Kolpakov, Viktor V.; Tomilova, Evgenia A.; Sapozhenkova, Ekaterina V.; Maslov, Leonid N.

doi:10.61186/ibj.3872

Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury

Authors

Nikita S. Voronkov ¹

Sergey V. Popov ¹

Natalia V. Naryzhnaya ¹

N. Rajendra Prasad ²

Ivan M. Petrov ³

Viktor V. Kolpakov ³

Evgenia A. Tomilova ³

Ekaterina V. Sapozhenkova ³

Leonid N. Maslov ¹

¹ Cardiology Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia

² Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India

³ Tyumen State Medical University, Tyumen, Russia

10.61186/ibj.3872

Abstract

Despite the unconditional success achieved in the treatment and prevention of AMI over the past 40 years, mortality in this disease remains high. Hence, it is necessary to develop novel drugs with mechanism of action different from those currently used in clinical practices. Studying the molecular mechanisms involved in the cardioprotective effect of adapting to cold could contribute to the development of drugs that increase cardiac tolerance to the impact of ischemia/reperfusion. An analysis of the published data shows that the long-term human stay in the Far North contributes to the occurrence of cardiovascular diseases. At the same time, chronic and continuous exposure to cold increases tolerance of the rat heart to ischemia/ reperfusion. It has been demonstrated that the cardioprotective effect of cold adaptation depends on the activation of ROS production, stimulation of the β₂-adrenergic receptor and protein kinase C, MPT pore closing, and K_ATP channel.

Keywords

acclimatization

Cold Temperature

Heart

Ischemia

Reperfusion