Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer

Alikhani, Mehdi; Esmaeili, Maryam; Tashakoripour, Mohammad; Mohagheghi, Mohammad Ali; Eshagh Hosseini, Mahmoud; Touati, Eliette; Vosough, Massoud; Mohammadi, Marjan

doi:10.52547/ibj.3847

Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer

Authors

Mehdi Alikhani ¹

Maryam Esmaeili ¹

Mohammad Tashakoripour ²

Mohammad Ali Mohagheghi ³

Mahmoud Eshagh Hosseini ²

Eliette Touati ⁴

Massoud Vosough ⁵

Marjan Mohammadi ¹

¹ HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

² Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran

³ Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

⁴ Institut Pasteur, Unit of Helicobacter Pathogenesis, CNRS UMR2001, 25-28 Rue du Dr Roux, 75724 Paris Cedex 15, France

⁵ Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

10.52547/ibj.3847

Abstract

Background: The role of inflammatory cytokines, such as tumor necrosis- alpha (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated.

Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.

Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups.

Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.

Keywords

Inflammation

Interleukin-8

Cytokines

Tumor Necrosis Factor-alpha