The Effects of Altered Ultrasound Parameters on the Recovery of Sciatic Nerve Injury

Akhlaghi, Zhamak; Izadi Mobarakeh, Jalal; Mokhtari, Mehrdad; Behnam, Hamid; Rahimi, Amir Abbas; Khajeh Hosseini, Mohammad Saleh; Samiee, Farzaneh

doi:10.6091/IBJ.942.2012

The Effects of Altered Ultrasound Parameters on the Recovery of Sciatic Nerve Injury

Authors

Zhamak Akhlaghi

Jalal Izadi Mobarakeh

Mehrdad Mokhtari

Hamid Behnam

Amir Abbas Rahimi

Mohammad Saleh Khajeh Hosseini

Farzaneh Samiee

10.6091/IBJ.942.2012

Abstract

Background: Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. Methods: NMRI mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly selected. The animals were exposed to ultrasound radiation with various frequencies, intensities, and exposure time. They were allocated into 20 groups (19 treatment and 1 control groups). Sciatic functional index (SFI) test was used to evaluate the difference between the groups with respect to functional efficiency of the sciatic nerve and its recovery. Results: The results of SFI test obtained from the 14th day showed a significant difference among the groups (P<0.05). On the 14th day after treatment, one of the groups (US11) recovered up to 90%. Conclusion: Altered ultrasound exposure parameters had more favorable outcomes compared with our previous work.

Keywords

Sciatic nerve

Ultrasonic therapy

regeneration