The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyzoites were detected in peritoneal exudates of the immunized mice 10 days after challenge. These results indicate that the vaccination with γ-irradiated tachyzoites not only protects the mice against challenge infection, but may circumvent the danger of the vaccine being life-threatening because of remaining tachyzoites inside macrophages posing as a latent infection.
Assmar, M., Hajizadeh Manjili, M., Esmaeili-Rastaghi, A. R., Farahmand, M., Piazak, N., Rafati, S. & Naddaf Dezfooli, S. R. (1999). Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice. Iranian Biomedical Journal, 3(3), 93-97.
MLA
Assmar, M., Hajizadeh Manjili, M., Esmaeili-Rastaghi, A. R., Farahmand, M., Piazak, N., Rafati, S., & Naddaf Dezfooli, S. R. "Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice", Iranian Biomedical Journal, 3, 3, 1999, 93-97.
HARVARD
Assmar M., Hajizadeh Manjili M., Esmaeili-Rastaghi A. R., Farahmand M., Piazak N., Rafati S., Naddaf Dezfooli S. R. (1999). 'Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice', Iranian Biomedical Journal, 3(3), pp. 93-97.
CHICAGO
M. Assmar, M. Hajizadeh Manjili, A. R. Esmaeili-Rastaghi, M. Farahmand, N. Piazak, S. Rafati & S. R. Naddaf Dezfooli, "Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice," Iranian Biomedical Journal, 3 3 (1999): 93-97,
VANCOUVER
Assmar M., Hajizadeh Manjili M., Esmaeili-Rastaghi A. R., Farahmand M., Piazak N., Rafati S., Naddaf Dezfooli S. R. Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice. Iranian Biomedical Journal. 1999;3(3):93-97.
Iranian Biomedical Journal