Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism.
Haghighi, B. & Farsadi, M. (2001). Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats. Iranian Biomedical Journal, 5(2), 103-106.
MLA
Haghighi, B., & Farsadi, M. "Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats", Iranian Biomedical Journal, 5, 2, 2001, 103-106.
HARVARD
Haghighi B., Farsadi M. (2001). 'Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats', Iranian Biomedical Journal, 5(2), pp. 103-106.
CHICAGO
B. Haghighi & M. Farsadi, "Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats," Iranian Biomedical Journal, 5 2 (2001): 103-106,
VANCOUVER
Haghighi B., Farsadi M. Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats. Iranian Biomedical Journal. 2001;5(2):103-106.
Iranian Biomedical Journal