Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed in human melanoma tumors grafted in the nude mice 24 h after injection of Gd-TCP and Gd-H, respectively. The percent of injected Gd, that localized to the tumor and measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES), was approximately 21% for Gd-TCP and 28% for Gd-H. A higher concentration of Gd was achieved compared with control indicating selective delivery of Gd-porphyrins to the melanoma xenografts. The data indicate that Gd-TCP can be used as a dual probe for diagnosis in MR imaging and for therapy in boron neutron capture therapy (BNCT).
Shahbazi-Gahrouei, D., Williams, M. & Allen, B. J. (2001). Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice. Iranian Biomedical Journal, 5(Issue 2 & 3), 87–95.
MLA
Shahbazi-Gahrouei, D., Williams, M., & Allen, B. J. "Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice", Iranian Biomedical Journal, 5, Issue 2 & 3, 2001, 87–95.
HARVARD
Shahbazi-Gahrouei, D., Williams, M., & Allen, B. J. (2001). 'Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice', Iranian Biomedical Journal, 5(Issue 2 & 3), pp. 87–95.
CHICAGO
Shahbazi-Gahrouei, D., Williams, M. & Allen, B. J., "Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice." Iranian Biomedical Journal, 5 Issue 2 & 3 (2001): 87–95,
VANCOUVER
Shahbazi-Gahrouei D., Williams M., Allen B. J. Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice. Iranian Biomedical Journal. 2001;5(Issue 2 & 3):87–95.
