A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. Our results indicate significantly decreased production of HBsAg-induced IL-12 in non-responder subjects compared to responders (P<0.01). Since IL-12 is produced mainly by antigen presenting cells (APC) and is considered to be crucial for initiation and polarization of CD4+ T-cell function, therefore, our findings could be interpreted to imply APC dysfunction in non-responder vaccinees
Jafarzadeh, A., Kardar, G. A., Khoshnoodi, J. & Shokri, F. (2004). Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine. Iranian Biomedical Journal, 8(1), 41–45.
MLA
Jafarzadeh, A., Kardar, G. A., Khoshnoodi, J., & Shokri, F. "Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine", Iranian Biomedical Journal, 8, 1, 2004, 41–45.
HARVARD
Jafarzadeh, A., Kardar, G. A., Khoshnoodi, J., & Shokri, F. (2004). 'Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine', Iranian Biomedical Journal, 8(1), pp. 41–45.
CHICAGO
Jafarzadeh, A., Kardar, G. A., Khoshnoodi, J. & Shokri, F., "Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine." Iranian Biomedical Journal, 8 1 (2004): 41–45,
VANCOUVER
Jafarzadeh A., Kardar G. A., Khoshnoodi J., Shokri F. Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine. Iranian Biomedical Journal. 2004;8(1):41–45.
