Volume 25, Issue 2 (3-2021)                   IBJ 2021, 25(2): 93-98 | Back to browse issues page

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Akhavan Attar F, Oloomi M, Irani S, Azizi M, Geranpayeh L. LncRNAs AK058003 and MVIH Overexpression in the Blood Samples of Iranian Breast Cancer Patients. IBJ 2021; 25 (2) :93-98
URL: http://ibj.pasteur.ac.ir/article-1-3299-en.html
Background: LncRNAs are considered as novel biological regulators and potential cancer biomarkers. LncRNAs MVIH and AK058003 are associated with microvascular invasion in HCC. In BC, upregulated MVIH and AK058003 expression levels have been shown to promote cell proliferation, though LncRNA-AK058003 acts as a tumor suppressor in HCC. Methods: Blood samples were collected from 30 healthy women and 30 female BC patients. RNA was extracted from the blood of both groups, and cDNA was then synthesized. Real-time PCR was used to measure the expression level of LncRNA-AK058003 and MVIH. Results: The expression level of two LncRNAs in the blood samples of BC patients increased significantly compared with healthy individuals. The levels of AK058003 and MVIH were not associated with lymph node metastasis (p = 0.402 and p = 0.39), tumor size (p = 0.76 and p = 0.461), and TNM stage (p = 0.574 and p = 0.711), respectively. Conclusion: As per our findings, LncRNA-AK058003 could serve as a suitable indicator for low stage of BC. In addition, the increased level of LncRNA-MVIH could be considered as a biomarker for BC, which needs more evaluation in the future.
Type of Study: Full Length/Original Article | Subject: Cancer Biology

1. Lei B, Xu SP, Liang XS, Li YW, Zhang JF, Zhang GQ, Pang D. Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer. Tumor biology 2016; 37(4): 5257-5264. [DOI:10.1007/s13277-015-4360-8]
2. Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biological research 2017; 50(1): 33. [DOI:10.1186/s40659-017-0140-9]
3. Bidgoli SA, Ahmadi R, Djamali avarhei M. Role of hormonal and environmental factors on early incidence of breast cancer in Iran. Science of the total environment 2010; 408(19): 4056-4061. [DOI:10.1016/j.scitotenv.2010.05.018]
4. Cerk S, Schwarzenbacher D, Adiprasito JB, Stotz M, Hutterrer GC, Gerger A, Ling H, Callin GA, Pichler M. Current status of long non-coding RNAs in human breast cancer. International journal of molecular sciences 2016; 17(9): 1485. [DOI:10.3390/ijms17091485]
5. Brunner AL, Beck AH, Edris B, Sweeney RT, Zhu SX, Li R, Montgomery K, Varma S, Gilks T, Guo X, Foley JW, Witten DM, Giacomini CP, Flynn RA, Pollack JR, Tibshirani R, Chang HY, van de Rijn M, West RB. Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. Genome biology 2012; 13(8): R75. [DOI:10.1186/gb-2012-13-8-r75]
6. Zhang K, Luo Z, Zhang Y, Song X, Zhang L, Wu L, Liu J. Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis. Oncology letters 2017; 14(2): 1895-1904. [DOI:10.3892/ol.2017.6462]
7. Braconi C, Patel T. Non-coding RNAs as therapeutic targets in hepatocellular cancer. Current cancer drug targets 2012; 12(9): 1073-1080. [DOI:10.2174/156800912803987904]
8. Wang Y, Liu X, Zhang H, Sun L, Zhou Y, Jin H, Zhang H, Zhang H, Liu J, Guo H, Nie Y, Wu K, Fan D, Zhang H, Liu L. Hypoxia-inducible lncRNA-AK058003 promotes gastric cancer metastasis by targeting γ-synuclein. Neoplasia 2014; 16(12): 1094-1106. [DOI:10.1016/j.neo.2014.10.008]
9. Wang CY, Hua L, Yao KH, Chen JT, Zhan JJ, Hu JH. Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. International journal of clinical and experimental pathology 2015; 8(1): 779-785.
10. Xiaoqin H, Zheng Y, Zhang Y, Gan Y, Zhou Y, Liang H, Wu D, Ge W, Deng J, Xu X. Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of Υ-synuclein in hepatocellular carcinoma cells. Oncotarget 2017; 8(6): 9451-9465. [DOI:10.18632/oncotarget.14276]
11. Yuan SX, Yang F, Yang Y, Tao QF, Zhang J, Huang G, Yang Y, Wang RY, Yang S, Huo XS, Zhang L, Wang F, Sun SH, Zhou WP. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence‐free survival after hepatectomy. Hepatology 2012; 56(6): 2231-2241. [DOI:10.1002/hep.25895]
12. Nie F-q, Zhu Q, Xu T-p, Zou Yf, Xie M, Sun M,Xia R, Lu KH. Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. Tumor biology 2014; 35(8):7587-7594. [DOI:10.1007/s13277-014-2009-7]
13. Weiss-Salz I, Harlap S, Friedlander Y, Kaduri L, Levy-Lahad E, Yanetz R, Dutsh L, Hochner H, Paltiel O. Ethnic ancestry and increased paternal age are risk factors for breast cancer before the age of 40 years. European journal of cancer prevention 2007; 16(6): 549-554. [DOI:10.1097/CEJ.0b013e328032783f]
14. Spizzo R, Almeida MIe, Colombatti A, Calin GA. Long non-coding RNAs and cancer: a new frontier of translational research? Oncogene 2012; 31(43): 4577-4587. [DOI:10.1038/onc.2011.621]
15. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, Zheng SS. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Annals of surgical oncology 2011; 18(5): 1243-1250. [DOI:10.1245/s10434-011-1581-y]
16. Gerasimova E, Audit B, Roux SG, Khalil A, Gileva O, Françoise A, Naimark O, Arneodo A. Wavelet-based multifractal analysis of dynamic infrared thermograms to assist in early breast cancer diagnosis. Frontiers in physiology 2014; 5: 176. [DOI:10.3389/fphys.2014.00176]
17. Hauptman N, Glavač D. Long non-coding RNA in cancer. International journal of molecular sciences 2013; 14(3): 4655-4669. [DOI:10.3390/ijms14034655]
18. Shi Y, Li J, Liu Y, Ding J, Fan Y, Tian Y, Wang L, Lian Y, Wang K, Shu Y. The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. Molecular cancer 2015; 14: 51. [DOI:10.1186/s12943-015-0318-0]
19. Cai, Jing H, Zhang D. Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway. Oncotargets and therapy 2015; 8: 2657-2664. [DOI:10.2147/OTT.S90485]
20. Zhen-Lin N, Wang YS, Mei YP, Lin X, Zhang GX, Sun HL, Wang YL, Xia YX, Wang SK. Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer. Journal of clinical laboratory analysis 2018; 32(1): e22193. [DOI:10.1002/jcla.22193]
21. Zemel S, Bartolomei MS, Tilghman SM. Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nature genetics 1992; 2(1): 61-65. [DOI:10.1038/ng0992-61]
22. Collette J, Le Bourhis X, Adriaenssens E. Regulation of human breast cancer by the long non-coding RNA H19. International journal of molecular sciences 2017; 18(11): 2319. [DOI:10.3390/ijms18112319]
23. He K, Wang P. Unregulated long non coding RNA AK058003 promotes the proliferation, invasion and metastasis of breast cancer by regulating the expression levels of the γ synuclein gene. Experimental and therapeutic medicine 2015; 9(5):1727-1732. [DOI:10.3892/etm.2015.2323]
24. Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circulation research 2014; 114(10): 1569-1575. [DOI:10.1161/CIRCRESAHA.114.303915]
25. Tsui NB, Ng EK, Lo YMD. Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clinical chemistry 2002; 48(10): 1647-1653. [DOI:10.1093/clinchem/48.10.1647]
26. Shin, VY, Chen J, Cheuk IWY, Siu MT, Ho CW, Wang X, Jin H, Kwong A. Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness. Cell death and disease 2019; 10: 270. [DOI:10.1038/s41419-019-1513-5]
27. Liu M, Gou L, Xia J, Wan Q, Jiang Y, Sun S, Tang M, He T, Zhang Y. LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells through up-regulating ITGB2. International journal of molecular sciences 2018; 19(7): 1866. [DOI:10.3390/ijms19071866]

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