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Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer
Pegah Larki , Alireza Ahadi , Ali Zare , Shahriar Tarighi , Mahrokh Zaheri , Mojgan Souri , Mohammad Reza Zali , Hamid Ghaedi , Mir Davood Omrani
Background: Differential expression profile of microRNAs (miRNAs) could be a diagnosis signature for the monitoring of gastric cancer (GC) progression. In this study, we focus on the comparison of expression levels of miR-21, miR-25, miR-93, miR-106b, and miR-375 during the sequential pattern of GC development, including normal gastric, gastric dysplasia, and GC sample. Methods: We used SYBR Green-based quantitative-PCR to quantify miRNAs expression. Results: Our analysis revealed the increased expression levels of miR-21 (p = 0.034), miR-25 (p = 0.0003) miR-93 (p = 0.0406), and miR-106b (p = 0.023) in GC samples. In addition, GC patients with positive lymph node metastasis showed the up-regulation of miR-25, miR-93, and miR-106b (p < 0.05). Conclusion: Our findings suggested that miR-21, miR-25, miR-93, and miR-106b altered expression in GC, and some of them may be further investigated as biomarkers for GC early detection and prognosis prediction.
Keywords: Biomarkers, microRNAs, Stomach cancer
Full-Text [PDF 944 kb]      
Type of Study: Full Length | Subject: Molecular Genetics & Genomics
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