:: Volume 22, Issue 6 (11-2018) ::
ibj 2018, 22(6): 367-373 Back to browse issues page
Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer
Pegah Larki , Alireza Ahadi , Ali Zare , Shahriar Tarighi , Mahrokh Zaheri , Mojgan Souri , Mohammad Reza Zali , Hamid Ghaedi , Mir Davood Omrani *
Abstract:  
Background: Differential expression profile of microRNAs (miRNAs) could be a diagnosis signature for monitoring gastric cancer (GC) progression. In this study, we focus on the comparison of expression levels of miR-21, miR-25, miR-93, miR-106b, and miR-375 during the sequential pattern of GC development, including normal gastric, gastric dysplasia, and GC sample. Methods: We used SYBR Green-based quantitative-PCR to quantify miRNAs expression. Results: Our analysis revealed the increased expression levels of miR-21 (p = 0.034), miR-25 (p = 0.0003), miR-93 (p = 0.0406), and miR-106b (p = 0.023) in GC samples. In addition, GC patients with positive lymph node metastasis showed the up-regulation of miR-25, miR-93, and miR-106b (p < 0.05). Conclusion: Our findings suggested that the expression of miR-21, miR-25, miR-93, and miR-106b altered in GC, and some of them may be further investigated as biomarkers for GC early detection and prognosis prediction. 
Keywords: Biomarkers, microRNAs, Stomach cancer
Full-Text [PDF 1042 kb]      
Type of Study: Full Length | Subject: Molecular Genetics & Genomics
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Larki P, Ahadi A, Zare A, Tarighi S, Zaheri M, Souri M, et al . Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer. ibj. 2018; 22 (6) :367-373
URL: http://ibj.pasteur.ac.ir/article-1-2441-en.html


Volume 22, Issue 6 (11-2018) Back to browse issues page
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