:: Volume 22, Issue 3 (5-2018) ::
IBJ 2018, 22(3): 142-150 Back to browse issues page
Genetic and Epigenetic of Medullary Thyroid Cancer
Fatemeh Khatami , Seyed Mohammad Tavangar
Medullary thyroid carcinoma (MTC) is an infrequent calcitonin-producing neuroendocrine tumor that initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, HRAS, and KRAS are the most important genes that are characterized in MTC. From the epigenetic perspective, Ras-association domain family member 1A, telomerase reverse transcriptase promoter methylations, overexpression of histone methyltransferases, EZH2 and SMYD3, and wide ranging increase and decrease in non-coding RNAs can be responsible for medullary thyroid carcinogenesis.
Keywords: Thyroid carcinoma, Genetic markers, Proto-oncogene
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Type of Study: Review Article | Subject: Molecular Genetics & Genomics

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Volume 22, Issue 3 (5-2018) Back to browse issues page