Volume 1, Issue 4 (10-1997)                   IBJ 1997, 1(4): 1-9 | Back to browse issues page

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Duvall J, Kashanchi F. Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53. IBJ 1997; 1 (4) :1-9
URL: http://ibj.pasteur.ac.ir/article-1-873-en.html
Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53
Janet Duvall, Fatah Kashanchi *
Abstract:  
Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin in‌hibitor, namely p21 (Waf1). Therefore, it is proposed that a Tat/p53 complex in vivo may deregulate p53 responsive genes, hence allowing for deregulation of check point, which may lead to development of malignancies.
Keywords: HIV, TAT, Transcription, Cell cycle, p53
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