Volume 4, Issue 1 (1-2000)                   ibj 2000, 4(1): 51-55 | Back to browse issues page

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K. Ardestani S, Amani M, kariminia A. Restorative Effect of Vitamin E on some Immunological Parameters of Sub-Lethal γ-Irradiated BALB/c Mice . ibj. 2000; 4 (1) :51-55
URL: http://ibj.pasteur.ac.ir/article-1-861-en.html
Elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. Therefore, we made attempts to investigate the protective effect of vitamin E (vit-E), a biological antioxidant in BALB/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. Several groups of mice were selected and exposed to sub-lethal g -irradiation with or without vit-E supplementation. At the end of exposure, mice were immunized by either live attenuated Brucellamelitensis vaccine or sheep red blood cell (SRBC). Consequently, the following parameters were assayed: specific antibody response, delayed type hypersensitivity and lymphocyte proliferation. We showed that vit-E supplementation restored the immune response in g -irradiated mice. These findings might have implications for individuals who are at risk of exposure to ionizing radiation.
Type of Study: Full Length |

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