Iranian
Biomedical Journal
Volume 3, Issue 3 And 4 (7-1999)
IBJ 1999, 3(3 And 4): 93-97 |
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Assmar M, Hajizadeh Manjili M, Esmaeili-Rastaghi A R, Farahmand M, Piazak N, Rafati S et al . Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice. IBJ 1999; 3 (3 and 4) :93-97
URL: http://ibj.pasteur.ac.ir/article-1-841-en.html
URL: http://ibj.pasteur.ac.ir/article-1-841-en.html
Mehdi Assmar * 
, Masoud Hajizadeh Manjili , Ahmad R. Esmaeili-Rastaghi , Mahin Farahmand , Nourair Piazak , Sima Rafati , Saied Reza Naddaf Dezfooli
, Masoud Hajizadeh Manjili , Ahmad R. Esmaeili-Rastaghi , Mahin Farahmand , Nourair Piazak , Sima Rafati , Saied Reza Naddaf Dezfooli
Abstract:
The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyzoites were detected in peritoneal exudates of the immunized mice 10 days after challenge. These results indicate that the vaccination with γ-irradiated tachyzoites not only protects the mice against challenge infection, but may circumvent the danger of the vaccine being life-threatening because of remaining tachyzoites inside macrophages posing as a latent infection.
Type of Study: Full Length/Original Article |
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