Volume 5, Issue 2 And 3 (3-2001)                   IBJ 2001, 5(2 And 3): 103-106 | Back to browse issues page

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Haghighi B, Farsadi M. Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats. IBJ 2001; 5 (2 and 3) :103-106
URL: http://ibj.pasteur.ac.ir/article-1-633-en.html

Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism.

Type of Study: Short Communication |

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