Volume 4, Issue 4 (10-2000)                   ibj 2000, 4(4): 129-131 | Back to browse issues page

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Zavareh A. Immunogenicity of BHK-Rabies Vaccine in Cattle . ibj. 2000; 4 (4) :129-131
URL: http://ibj.pasteur.ac.ir/article-1-593-en.html

In this study, the immunogenicity of a rabies vaccine that was used in one of the Isfahan cattle farms is reported. This vaccine was produced by replication of the Pasteur virus (PV) strain on BHK-21 monolayer cell culture. The virus suspension was inactivated by ß-propiolactone treatment and the harvested pool showed sterility and safety. Thus, the obtained vaccine was tested on mice and a satisfactory immune response was observed. Thereafter, the vaccine was tested on 34 cattle divided into 2 groups. Each group was received a different dose of the vaccine intramuscularly. Sera were taken 2 months after rabies vaccination and were analyzed by the rapid fluorescence focus inhibition test (RFFIT) to evaluate the titer of the rabies-neutralizing antibody. Both groups under study showed a sufficient seroconversion.

Type of Study: Short Communication |

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