Volume 6, Issue 4 (10-2002)                   ibj 2002, 6(4): 135-140 | Back to browse issues page

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Mousavi Hosseini K, Rezvan H, Motalleb Z, Chabokpey S, Mirbod V. Study of the Heat-Treated Human Albumin Stabilization by Caprylate and Acetyltryptophanate . ibj. 2002; 6 (4) :135-140
URL: http://ibj.pasteur.ac.ir/article-1-559-en.html
Sodium salt of N-acetyl-DL-tryptophan (AT) and octanoic acid (caprylic acid CA) individually and in combination were studied as thermal stabilizer with different concentrations in heat treatment of human albumin solution. HPLC protein profiles before pasteurization of albumin showed less than 1% polymer. In free stabilizer albumin solution during pasteurization visible clot was formed. But by using variation of the above mentioned stabilizers, the amount of polymer was increased to about 4% during pasteurization (60° C, 10 h). By increasing the heat to the visible clot formation point, the most effective stabilizer against visible clot formation was found to be CA. However, in drug formulation it is important to choose the variety and concentration of stabilizers in accordance with regulations.
Type of Study: Full Length |

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