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Biomedical Journal
Volume 28, Issue 7 (Special Issue 2024)
IBJ 2024, 28(7): 411-411 |
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Hooshmand A, Abdipour N, Zavvar M. Relationship Between Serum Ghrelin Hormone Levels and Fertility Factors in Men: A Systematic Review. IBJ 2024; 28 (7) :411-411
URL: http://ibj.pasteur.ac.ir/article-1-4848-en.html
URL: http://ibj.pasteur.ac.ir/article-1-4848-en.html
Abstract:
Introduction: Ghrelin, a multifaceted peptide hormone primarily produced in the stomach and gastrointestinal tract, exhibits diverse physiological effects. Notably, it stimulates growth hormone release and plays a key role in regulating appetite. While ghrelin receptors are present in testicular tissue, the direct impact of ghrelin on human spermatogenesis and male fertility remains uncertain. Although animal studies suggest that ghrelin administration can influence sperm production and quality, further research is needed to establish its role in human reproductive health. Therefore, this review evaluates the relationship between ghrelin and men's fertility factors.
Search Strategy: PRISMA guidelines and Cochrane systematic review principles were adhered to in this systematic review. A comprehensive search was conducted across key databases (PubMed, Scopus, and Web of Science) using specific keywords related to 'Ghrelin,' 'Spermatogenesis,' 'Fertility,' and their synonyms. Additionally, grey literature was explored through the Google Scholar search engine. Observational studies investigating serum ghrelin levels in men and their association with fertility factors were included. Review articles, conference papers, letters to the editor, and case reports were excluded. The studies were independently screened, data extraction was performed, and the quality of the included studies was assessed using the Newcastle-Ottawa scale by two authors. Relevant information was organized into an extraction table.
Results: A total of 1125 articles were involved in PubMed, Scopus, and Web of Science. One hundred forty-five duplicate articles were excluded. Nine hundred eighty articles were screened, and 970 titles and abstracts were irrelevant. Ten studies finally remained, and these had essential conditions for analysis. A key outcome observed in these studies was the remarkable relevance of ghrelin to serum testosterone, sperm concentration, and gonadotropin hormones. The most apparent correlation between serum testosterone levels and ghrelin levels demonstrates an undeniable association. Additionally, factors such as age, weather, and other hormones like “Leptin” and “Obestatin” were found to affect this correlation.
Conclusion and Discussion: The results of the current study suggest a significant association between ghrelin and fertility factors. However, the mentioned articles reported the correlation between ghrelin and fertility differently. Additional studies are needed to explore the exact relationship between ghrelin and spermatogenesis.
Search Strategy: PRISMA guidelines and Cochrane systematic review principles were adhered to in this systematic review. A comprehensive search was conducted across key databases (PubMed, Scopus, and Web of Science) using specific keywords related to 'Ghrelin,' 'Spermatogenesis,' 'Fertility,' and their synonyms. Additionally, grey literature was explored through the Google Scholar search engine. Observational studies investigating serum ghrelin levels in men and their association with fertility factors were included. Review articles, conference papers, letters to the editor, and case reports were excluded. The studies were independently screened, data extraction was performed, and the quality of the included studies was assessed using the Newcastle-Ottawa scale by two authors. Relevant information was organized into an extraction table.
Results: A total of 1125 articles were involved in PubMed, Scopus, and Web of Science. One hundred forty-five duplicate articles were excluded. Nine hundred eighty articles were screened, and 970 titles and abstracts were irrelevant. Ten studies finally remained, and these had essential conditions for analysis. A key outcome observed in these studies was the remarkable relevance of ghrelin to serum testosterone, sperm concentration, and gonadotropin hormones. The most apparent correlation between serum testosterone levels and ghrelin levels demonstrates an undeniable association. Additionally, factors such as age, weather, and other hormones like “Leptin” and “Obestatin” were found to affect this correlation.
Conclusion and Discussion: The results of the current study suggest a significant association between ghrelin and fertility factors. However, the mentioned articles reported the correlation between ghrelin and fertility differently. Additional studies are needed to explore the exact relationship between ghrelin and spermatogenesis.
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