Iranian
Biomedical Journal
Volume 28, Issue 7 (Special Issue 2024)
IBJ 2024, 28(7): 319-319 |
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Jalali P, Golpayegani A. COVID-19 Vaccine Effectiveness on the Severity of Disease: A Case-Control Study in Southeastern Iran. IBJ 2024; 28 (7) :319-319
URL: http://ibj.pasteur.ac.ir/article-1-4755-en.html
URL: http://ibj.pasteur.ac.ir/article-1-4755-en.html
COVID-19 Vaccine Effectiveness on the Severity of Disease: A Case-Control Study in Southeastern Iran
Abstract:
Introduction: Considering the importance of the effectiveness of vaccination in reducing the severity of COVID-19 and mortality, knowledge of the effect of the vaccine on the severity of COVID-19 in communities is critical. Therefore, this study aimed to evaluate the effect of COVID-19 vaccines on the severity of COVID-19 in southeastern Iran (the Bam region).
Methods and Materials: A case-control study of a total of 2,082 adults aged 18 years was conducted to evaluate the associations between hospitalization due to COVID-19 and previous vaccination with existing vaccines (including Sinopharm, AstraZeneca and CovIran Barkat) in the country. Multinomial logistic regression was used, and relative risk (RR) and 95% confidence intervals (CIs) were calculated.
Results: After controlling for potential confounders, multinomial logistic regression revealed that COVID-19 vaccination reduced the likelihood of hospitalization for males and females in temporary wards (RRmen = 0.22 vs. RRwomen = 0.34), general wards (RRmen = 0.25 vs. RRwomen = 0.31), and intensive care units (RRmen = 0.47 vs. RRwomen = 0.77), with a p value of 0.001. The RR of hospitalization in all wards decreased for men and women who received Sinopharm or AstraZeneca and for women who received the Barkat vaccine. However, only a significant difference was detected in the reduction in patients who received the Sinopharm vaccine (p = 0.001).
Conclusion and Discussion: The findings show that vaccination is related to reducing the severity of the disease in the hospital. Therefore, increasing the vaccinated population can reduce the severity of COVID-19 and the need for intensive care in hospitals.
Methods and Materials: A case-control study of a total of 2,082 adults aged 18 years was conducted to evaluate the associations between hospitalization due to COVID-19 and previous vaccination with existing vaccines (including Sinopharm, AstraZeneca and CovIran Barkat) in the country. Multinomial logistic regression was used, and relative risk (RR) and 95% confidence intervals (CIs) were calculated.
Results: After controlling for potential confounders, multinomial logistic regression revealed that COVID-19 vaccination reduced the likelihood of hospitalization for males and females in temporary wards (RRmen = 0.22 vs. RRwomen = 0.34), general wards (RRmen = 0.25 vs. RRwomen = 0.31), and intensive care units (RRmen = 0.47 vs. RRwomen = 0.77), with a p value of 0.001. The RR of hospitalization in all wards decreased for men and women who received Sinopharm or AstraZeneca and for women who received the Barkat vaccine. However, only a significant difference was detected in the reduction in patients who received the Sinopharm vaccine (p = 0.001).
Conclusion and Discussion: The findings show that vaccination is related to reducing the severity of the disease in the hospital. Therefore, increasing the vaccinated population can reduce the severity of COVID-19 and the need for intensive care in hospitals.
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