Iranian
Biomedical Journal
Volume 28, Issue 7 (Special Issue 2024)
IBJ 2024, 28(7): 236-236 |
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Albabay A, Sharifabad A H, Yegdaneh A, Tavakolizadeh M, Dabaghydost H. Effect of Malva neglecta Total Extract on Bleomycin-Induced Pulmonary Fibrosis in Rats. IBJ 2024; 28 (7) :236-236
URL: http://ibj.pasteur.ac.ir/article-1-4659-en.html
URL: http://ibj.pasteur.ac.ir/article-1-4659-en.html
Amir Albabay 
, Ali Hosseini Sharifabad * , Afsaneh Yegdaneh , Mahdi Tavakolizadeh , Hamide Dabaghydost
, Ali Hosseini Sharifabad * , Afsaneh Yegdaneh , Mahdi Tavakolizadeh , Hamide Dabaghydost
Abstract:
Introduction: Idiopathic pulmonary fibrosis is a chronic and progressive respiratory disease. Malva neglecta possesses significant anti-inflammatory and antioxidant activities. This study investigated the therapeutic effects of hydroalcoholic extract of this plane species on pulmonary fibrosis induced by bleomycin (BLM).
Methods and Materials: Male Wistar rats (n = 36; 180-200 g) were randomly divided into six groups (n = 6). The control group (Group I) received normal saline intratracheally (single dose) on day one. Other groups received a single dose of BLM (7.5 IU/Kg) intratracheally on the first day. The animals were then fed daily for 28 days as follows: normal saline (Group II), pirfenidone (Group III), 300, 600, and 900 mg/kg Malva neglecta extract (Groups IV, V, and VI, respectively). The rats were finally euthanized, and the lung tissues were removed for histological analysis and biochemical assessments.
Result: Intratracheal administration of BLM significantly increased the lung tissue levels of hydroxyproline, malondialdehyde, and free radicals compared to the control group (p = 0.001). Malva neglecta at the dose of 900 mg/kg significantly prevented the increase of these factors compared to the BLM group (p = 0.001). At the same dosage, the plant significantly decreased the aforementioned factors in comparison to its lower dosage (p = 0.01). Lung tissues in BLM-treated groups showed severe tissue damage. In addition, hydroalcoholic extracts of Malva neglecta prevented the pathological damage of BML on the lung tissue.
Conclusion and Discussion: Our findings indicate that the total extract of Malva neglecta may be effective in treating pulmonary fibrosis induced by BLM. This effect is likely associated with anti-inflammatory and antioxidant properties of the Malva neglecta extract.
Methods and Materials: Male Wistar rats (n = 36; 180-200 g) were randomly divided into six groups (n = 6). The control group (Group I) received normal saline intratracheally (single dose) on day one. Other groups received a single dose of BLM (7.5 IU/Kg) intratracheally on the first day. The animals were then fed daily for 28 days as follows: normal saline (Group II), pirfenidone (Group III), 300, 600, and 900 mg/kg Malva neglecta extract (Groups IV, V, and VI, respectively). The rats were finally euthanized, and the lung tissues were removed for histological analysis and biochemical assessments.
Result: Intratracheal administration of BLM significantly increased the lung tissue levels of hydroxyproline, malondialdehyde, and free radicals compared to the control group (p = 0.001). Malva neglecta at the dose of 900 mg/kg significantly prevented the increase of these factors compared to the BLM group (p = 0.001). At the same dosage, the plant significantly decreased the aforementioned factors in comparison to its lower dosage (p = 0.01). Lung tissues in BLM-treated groups showed severe tissue damage. In addition, hydroalcoholic extracts of Malva neglecta prevented the pathological damage of BML on the lung tissue.
Conclusion and Discussion: Our findings indicate that the total extract of Malva neglecta may be effective in treating pulmonary fibrosis induced by BLM. This effect is likely associated with anti-inflammatory and antioxidant properties of the Malva neglecta extract.
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