Volume 28, Issue 1 (1-2024)                   IBJ 2024, 28(1): 8-14 | Back to browse issues page

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Jafari E, Soleymani N, Hamidi M, Rahi A, Rezaei A, Azizian* R. Celiac Disease: A Review from Genetic to Treatment. IBJ 2024; 28 (1) :8-14
URL: http://ibj.pasteur.ac.ir/article-1-4028-en.html
Celiac Disease: A Review from Genetic to Treatment
Erfaneh Jafari , Niloufar Soleymani , Masoud Hamidi * , Azar Rahi , Akram Rezaei , Reza Azizian*
Abstract:  
Celiac disease (CD) is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.
Keywords: Celiac disease, Dipeptidyl peptidase 4, HLA-DQ antigens, Probiotics
Full-Text [PDF 1129 kb]      
Type of Study: Mini-Review | Subject: Related Fields
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