Volume 27, Issue 6 (11-2023)                   IBJ 2023, 27(6): 326-339 | Back to browse issues page

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Mirzaei R, Khosrokhavar R, Arbabi Bidgoli S. The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis. IBJ 2023; 27 (6) :326-339
URL: http://ibj.pasteur.ac.ir/article-1-3965-en.html
The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
Roya Mirzaei * , Roya Khosrokhavar , Sepideh Arbabi Bidgoli
Abstract:  
The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
Keywords: Animal model, Fructose, Liver, Liver function tests, Oxidative stress
Full-Text [PDF 1686 kb]      
Type of Study: Review Article | Subject: Enzymology and Protein Chemistry
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