Iranian
Biomedical Journal
Volume 27, Issue 1 (1-2023)
IBJ 2023, 27(1): 66-71 |
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Alikhani M, Esmaeili M, Tashakoripour M, Mohagheghi M A, Eshagh Hosseini M, Touati E, et al . Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer. IBJ 2023; 27 (1) :66-71
URL: http://ibj.pasteur.ac.ir/article-1-3847-en.html
URL: http://ibj.pasteur.ac.ir/article-1-3847-en.html
Mehdi Alikhani 
, Maryam Esmaeili , Mohammad Tashakoripour , Mohammad Ali Mohagheghi , Mahmoud Eshagh Hosseini , Eliette Touati , Massoud Vosough , Marjan Mohammadi *
, Maryam Esmaeili , Mohammad Tashakoripour , Mohammad Ali Mohagheghi , Mahmoud Eshagh Hosseini , Eliette Touati , Massoud Vosough , Marjan Mohammadi *
Abstract:
Background: The role of inflammatory cytokines, such as tumor necrosis- alpha (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated.
Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.
Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups.
Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.
Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.
Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups.
Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.
Type of Study: Short Communication |
Subject:
Cancer Biology
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