Iranian
Biomedical Journal
Volume 10, Issue 2 (4-2006)
IBJ 2006, 10(2): 99-104 |
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Roghani M, Joghataie M T, Jalili M R, Baluchnejadmojarad T. Time Course of Changes in Passive Avoidance and Y-maze Performance in Male Diabetic Rats. IBJ 2006; 10 (2) :99-104
URL: http://ibj.pasteur.ac.ir/article-1-355-en.html
URL: http://ibj.pasteur.ac.ir/article-1-355-en.html
Mehrdad Roghani * 
, Mohammad Taghi Joghataie , Mohammad Reza Jalili , Tourandokht Baluchnejadmojarad
, Mohammad Taghi Joghataie , Mohammad Reza Jalili , Tourandokht Baluchnejadmojarad
Abstract:
Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin (STZ) was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of 1 st , 2 nd , and 3 rd months using passive avoidance and Y-maze tasks. It was found out that mean IL exhibits a significant increase only at the end of 2 nd (p<0.05) and 3 rd (p<0.01) months. In addition, STL significantly reduced at the end of 2 nd (p<0.05) and 3 rd months (p<0.01). Regarding Y-maze task, alternation score of the diabetic rats was lower than that of the control ones at the end of 1 st (p<0.05), 2 nd (p<0.01), and 3 rd (p<0.01) months as compared to time-matched control group. To conclude, at least one month is strictly required for development of behavioral disturbances in passive avoidance and Y-maze tasks in STZ-diabetic rats.
Keywords: Learning and memory, Cognition, Passive avoidance, Y-maze, Diabetic rat, Streptozotocin (STZ)
Type of Study: Full Length/Original Article |
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