Volume 26, Issue 2 (3-2022)                   ibj 2022, 26(2): 124-131 | Back to browse issues page

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aghayan S, azari G, seyedjafari E. Sustained release of Risedronate from PLGA micro-particles embedded in alginate hydrogel for treatment of bony lesions. ibj. 2022; 26 (2) :124-131
URL: http://ibj.pasteur.ac.ir/article-1-3480-en.html
Background: Inflammatory bone resorption in periodontitis can lead to tooth loss. Systemic administration of Bis-Phosphonates such as Risedronate for preventing bone resorption can cause adverse effects. Alginate hydrogel and PLGA microparticles have been studied as drug delivery systems for sustained release of drugs. So the release pattern of Risedronate from PLGA microparticles embedded with alginate hydrogel was studied as a drug delivery system for sustained release of the drug, which can be used in local administrations. Methods: Risedronate-containing PLGA microparticles were fabricated using double emulsion solvent evaporation technique. Ionic cross-linking method was used to fabricate Risedronate-loaded Alginate hydrogel. Risedronate-containing PLGA microparticles were then coated with Alginate hydrogel. The calibration curve of Risedronate was traced to measure encapsulation efficacy and study the release pattern. SEM imaging was carried out. Cell toxicity was examined using MTT assay. Statistical analyze of data was done using SPSS ver:20 software, via one way ANOVA and Tukey tests. Results: SEM imaging showed Open porosities on Alginate hydrogels. The mean encapsulation efficacy of PLGA microparticles for Risedronate was 57.14±3.70%. Risedronate released completely after 72h from Alginate hydrogel and the cumulative release was significantly higher (P=0.000) compared to PLGA microspheres coated with Alginate hydrogel, which showed sustained released of Risedronate until day 28. Risedronate-loaded Alginate hydrogel showed significant decrease in gingival fibroblasts cell viability (P<0.05). Conclusion: Alginate-coated PLGA microspheres seem to be an appropriate system for Risedronate delivery and in local applications; Considering the ability of controlled and sustained release and not showing cell toxicity.
Type of Study: Full Length | Subject: Pharmaceutical Biotechnology

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