Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum

Sepanjnia, Adel; Ghasemi, Hassan; Mohseni, Roohollah; Ranjbar, Akram; Shabani, Fatemeh; Salimi, Fouzieh; Kheiripour, Nejat

doi:10.29252/ibj.24.4.251

Volume 24, Issue 4 (7-2020) ibj 2020, 24(4): 251-256 | Back to browse issues page

DOI: 10.29252/ibj.24.4.251

PMID: 32306723

PMCID: PMC7275813

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Sepanjnia A, Ghasemi H, Mohseni R, Ranjbar A, Shabani F, Salimi F et al . Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum. ibj. 2020; 24 (4) :251-256
URL: http://ibj.pasteur.ac.ir/article-1-3040-en.html

Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum

Adel Sepanjnia

, Nejat Kheiripour

Abstract:

Background: The present study aimed to evaluate the effects of different concentrations of cerium oxide nanoparticles (CONPs) on the oxidative stress (OS) status in kidney, lung, and serum of rats. Methods: Male Wistar Rats were treated intraperitoneally with 15, 30, and 60 mg/kg/day of CONPs. The biochemical parameters, including total antioxidant capacity (TAC), total thiol group (TTG), malondialdehyde (MDA), SOD (superoxide dismutase), and catalase (CAT) were assayed in serum, kidney, and lung tissues. Results: MDA decreased, but TTG and CAT increased in serum by the administration of CONPs at 15 mg/kg. In kidney homogenate obtained from the group treated with CONPs at 15 mg/kg, TAC, TTG, and CAT significantly increased compared to the control group. However, CONPs at 15, 30, and 60 mg/kg significantly decreased MDA level compared to the control group. In lung tissue, CONPs in doses of 15, 30 and 60 mg/kg significantly decreased CAT activity, TTG and TAC compared to the control group, while in kidney tissue, CONPs at the concentrations of 30 and 60 mg/kg significantly increased MDA compared to the control group. Conclusion: Our findings suggest that CONPs attenuate OS in the kidney and affect the serum levels of OS-related markers but induce OS in the lung tissue in a dose-dependent manner.

Keywords: Kidney, Lung, Nanoparticles, Oxidative stress

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Type of Study: Full Length | Subject: Pharmaceutical Biotechnology

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