Iranian
Biomedical Journal
Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum
Adel Sepanjnia 
, Hassan Ghasemi , Roohollah Mohseni , Akram Ranjbar , Fatemeh Shabani , Fouzieh Salimi , Nejat Kheiripour *
, Hassan Ghasemi , Roohollah Mohseni , Akram Ranjbar , Fatemeh Shabani , Fouzieh Salimi , Nejat Kheiripour *
Abstract:
Background: The present study aimed to evaluate the effects of different concentrations of CONPs on the OS status in kidney, lung, and serum of rats. Methods: Male Wistar Rats were treated intraperitoneally with 15, 30, and 60 mg/kg/day of CONPs. The biochemical parameters, including TAC, TTG, MDA, SOD, and CAT were assayed in serum, kidney, and lung tissues. Results: MDA decreased, but TTG and CAT increased in serum by the administration of CONPs at 15 mg/kg. In kidney homogenate obtained from the group treated with CONPs at 15 mg/kg, TAC, TTG, and CAT significantly increased compared to the control group. However, CONPs at 15, 30, and 60 mg/kg significantly decreased MDA level compared to the control group. In lung tissue, CONPs in doses of 15, 30 and 60 mg/kg significantly decreased CAT activity, TTG and TAC compared to the control group, while in kidney tissue, CONPs at the concentrations of 30 and 60 mg/kg significantly increased MDA compared to the control group. Conclusion: Our findings suggest that CONPs attenuate OS in the kidney and affect the serum levels of OS-related markers but induce OS in the lung tissue in a dose-dependent manner.
Type of Study: Full Length |
Subject:
Pharmaceutical Biotechnology
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