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Background: The aim of this study was to evaluate the effects of ginger extract on preventing myelin degradation in a rat model of multiple sclerosis (MS). MS is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. Methods: This experimental research was conducted on 49 rats divided into four control groups, including the normal group, cuprizone-induced rats; a sham group that received cuprizone and sodium carboxymethyl cellulose (NaCMC), and the standard control group that received fingolimod + cuprizone, and also three experimental groups that received cuprizone and three doses of ginger extract: 150, 300, and 600 mg/kg/day. The Basket test and transmission electron microscopy technique were also performed in this study. Olig2 protein and Mbp genes and were measured by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. Results: Our results showed that ginger extract at a dose of 600 mg/kg prevented corpus callosum from demyelination; however, it showed no significant difference with Fingolimod groups (P-value > 0.05), whereas it showed a quite significant difference with the cuprizone group (P-value < 0.05). Conclusion: Our findings suggested that the consumption of ginger prevented demyelination and improved remyelination in the central nervous system in rats and may be used as a therapeutic agent in the prevention of MS.

Type of Study: Full Length | Subject: Related Fields

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