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Abstract:  
Background: Whooping cough (pertussis) is a highly contagious, acute respiratory illness of infants that is caused by the Gram-negative bacterium Bordetella pertussis. Despite the use of efficacious vaccine, the disease still remains a serious public health problem globally. Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in the evolutionary of B. pertussis. Methods: Herein, we describe the number of gene losses that likely contributed to adaptation of pathogen. A total of six epidemic B. pertussis isolates were selected based on PFGE phylogenetic dendrogram comparative genome content with reference genomes by whole genome sequencing. We also investigated the genome of two vaccine strains (Bp134 and Bp509) that included in Iranian pertussis vaccine. Results: Compared to the strain Tohama I, the current ptxP3 Iranian clinical isolates, like other ptxP3 isolates collected from countries using ACV, had lost two major RD, including RD3 (BP0910-BP0934) and RD5 (BP1130-BP1142), which contributed to the cell surface and transcriptional regulators. Conclusion: We confirm that gene losses are an ongoing feature of B. pertussis evolution.

     
Type of Study: Full Length | Subject: Molecular Microbiology

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