Iranian
Biomedical Journal
Volume 22, Issue 4 (7-2018)
IBJ 2018, 22(4): 231-236 |
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Heidary H, Pouresmaeili F, Mirfakhraie R, Omrani M D, Ghaedi H, Fazeli Z, et al . An Association Study between Longitudinal Changes
of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men. IBJ 2018; 22 (4) :231-236
URL: http://ibj.pasteur.ac.ir/article-1-2400-en.html
URL: http://ibj.pasteur.ac.ir/article-1-2400-en.html
Hamed Heidary 
, Farkhondeh Pouresmaeili 
, Reza Mirfakhraie , Mir Davood Omrani , Hamid Ghaedi , Zahra Fazeli , Shadi Sayban , Soudeh Ghafouri-Fard , Eznollah Azargashb , Fazlollah Shokri
, Farkhondeh Pouresmaeili , Reza Mirfakhraie , Mir Davood Omrani , Hamid Ghaedi , Zahra Fazeli , Shadi Sayban , Soudeh Ghafouri-Fard , Eznollah Azargashb , Fazlollah Shokri
Abstract:
Background: Telomeres are evolutionary, specialized terminal structures at the ends of eukaryotic chromosomes containing TTAGGG repeats in human. Several human diseases have been known to be associated with dramatic changes in telomere length. The aim of the present study was to assess the correlation between the relative leukocyte telomere length (LTL) and infertility in a group of Iranian azoospermic males. Methods: In this case-control pilot study, relative telomere length (RTL) of peripheral blood leukocytes from a total of 30 idiopathic non-obstructive azoospermic males and 30 healthy fertile males was evaluated using real-time PCR. RTL was calculated as T (telomere)/S (single copy gene) ratio and compared between infertile and fertile groups. Results: Patients with azoospermia showed significantly shorter RTL than fertile males (0.54 vs. 0.84, p < 0.05). The area under the receiver operating characteristic (ROC) curve was estimated to be 99.8%, suggesting LTL as a potential marker for the diagnosis of azoospermia. Conclusion: Our findings demonstrated a probable association between telomere shortening and azoospermia in a population of Iranian infertile men affected by idiopathic azoospermia.
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