:: Volume 22, Issue 4 (7-2018) ::
ibj 2018, 22(4): 217-230 Back to browse issues page
Molecular Signaling in Tumorigenesis of Gastric Cancer
Fatemeh Molaei, Mohammad Mahdi Forghanifard, Yasaman Fahim, Mohammad Reza Abbaszadegan *
Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies on multiple factors, including environmental and genetic characteristics. One of the most important environmental factors of GC occurrence is infection with Helicobacter pylori that is classified as class one carcinogens. Dysregulation of several genes and pathways play an essential role during gastric carcinogenesis. Dysregulation of developmental pathways such as Wnt/β-catenin signaling, Hedgehog signaling, Hippo pathway, Notch signaling, nuclear factor-kB, and epidermal growth factor receptor have been found in GC. Epithelial-mesenchymal transition, as an important process during embryogenesis and tumorigenesis, is supposed to play a role in initiation, invasion, metastasis, and progression of GC. Although surgery is the main therapeutic modality of the disease, the understanding of biological processes of cell signaling pathways may help to develop new therapeutic targets for GC.
Keywords: Beta Catenin, Epithelial-mesenchymal transition, Hedgehogs, Helicobacter pylori, NF-kappa B
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Type of Study: Study Break | Subject: Cancer Biology
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Molaei F, Forghanifard M M, Fahim Y, Abbaszadegan M R. Molecular Signaling in Tumorigenesis of Gastric Cancer. ibj. 2018; 22 (4) :217-230
URL: http://ibj.pasteur.ac.ir/article-1-2398-en.html

Volume 22, Issue 4 (7-2018) Back to browse issues page
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