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Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors
Farzaneh Darbeheshti, Pantea Izadi , Amir Nader Emami Razavi, Mir Saeed Yekaninejad, and Javad Tavakkoly Bazzaz
Abstract:  

Background: Previous studies have suggested that BRCA1 dysregulation has a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its association with the clinicopathologic characteristics of patients. Methods: BRCA1 expression was evaluated by real-time PCR in 26 triple-negative and 27 luminal breast tumors. Results: The results revealed that there is a high frequency of BRCA1 underexpression in both triple-negative and luminal breast tumors. The BRCA1 underexpression was related to young  age at diagnosis, lymph node involvement, and grade ІІІ tumors. Conclusion: The observations suggest that decreased BRCA1 expression, regardless of tumor subtype, has a general role in breast malignancy and associated with poor prognostic features in breast tumors.

Keywords: Breast cancer, BRCA1, Triple-negative breast neoplasm
Full-Text [PDF 591 kb]      
Type of Study: Short Communication | Subject: Cancer Biology
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PMID: 28646826


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Darbeheshti F, Izadi P, Emami Razavi A N, Yekaninejad M S, Tavakkoly Bazzaz A J. Comparison of BRCA1 Expression between Triple-Negative and Luminal Breast Tumors. IBJ. 2017;
URL: http://ibj.pasteur.ac.ir/article-1-2094-en.html
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