:: Volume 20, Issue 3 (7-2016) ::
IBJ 2016, 20(3): 152-160 Back to browse issues page
Association of two Common Single Nucleotide Polymorphisms (SNPs +45T/G and +276G/T) of ADIPOQ Gene with Coronary Artery Disease in Type 2 Diabetic Patients
Ghorban Mohammadzadeh , Mohammad-Ali Ghaffari , Habib Heibar , Mohammad Bazyar
Abstract:  

Background: Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of ADIOPQ gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM). Methods: Genotypes of two SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in 200 subjects with T2DM (100 subjects with CAD and 100 without CAD). Results: The frequency of TT genotype of +276G/T was significantly elevated in CAD compared to controls (χ2=7.967, P=0.019). A similar difference was found in the allele frequency of +276G/T between two groups (χ2=3.895, P=0.048). The increased risk of CAD was associated with +276 TT genotype when compared to reference GG genotype (OR=5.158; 95% CI=1.016-26.182, P=0.048). However, no similar difference was found in genotype and allele frequencies of SNP +45T/G between two groups. There was a CAD protective haplotype combination of +276 wild-type and +45 mutant-type allele (276G-45G) (OR=0.37, 95% CI=0.16-0.86, P=0.022) in the subject population. Conclusion: Our findings indicated that T allele of SNP +276G/T is more associated with the increased risk of CAD in subjects with T2DM. Also, a haplotype combination of +45G/+276G of these two SNPs has a protective effect on the risk of CAD.

Keywords: Adiponectin, Type 2 diabetes, Cronary artery disease, Single nucleotide polymorphisms
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Type of Study: Full Length | Subject: Related Fields
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Mohammadzadeh G, Ghaffari M, Heibar H, Bazyar M. Association of two Common Single Nucleotide Polymorphisms (SNPs +45T/G and +276G/T) of ADIPOQ Gene with Coronary Artery Disease in Type 2 Diabetic Patients. IBJ. 2016; 20 (3) :152-160
URL: http://ibj.pasteur.ac.ir/article-1-1618-en.html


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