:: Volume 19, Issue 4 (10-2015) ::
IBJ 2015, 19(4): 226-232 Back to browse issues page
Chlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus
Zahra Zamani , Samad Zare , Rajabali Sadrkhanlou , Abbas Ahmadi , Elham Movahed
Abstract:  

Background: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. Methods: Albino Wistar rats (n = 32) were divided into four groups. The first group was set as a control. In the three drug-treated groups (eight rats in each group), CPZ was administered by a gavage at doses of 3, 10, and 30 mg/kg/day for 28 days. One day after the last administration of the drug, the animals were sacrificed. Histopathological and histomorphometrical analyses of the uterine horns and mammary glands were carried out to evaluate dose-dependent effect of CPZ on histological structure. Serum levels of prolactin (PRL), estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were also evaluated. Results: Remarkable (P < 0.05) elevation was observed in CPZ-administrated animals' uterine horn endometrium, myometrium, and perimetrium thicknesses, and the mammary glands were observed with galactorrhea features. The serum level of progesterone and PRL significantly (P < 0.05) increased, while the serum concentration of LH, FSH, and estradiol was notably (P < 0.05) decreased depending on administrated CPZ dose. No histological and biological changes were occurred in the control animals. Conclusion: The present findings suggest that CPZ-induced disturbances not only depend on PRL level and increased PRL level largely depends on administrated doses of the CPZ.

Keywords: Hyperprolactinemia, Uterus, Rats
Full-Text [PDF 1116 kb]      
Type of Study: Full Length | Subject: Related Fields
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



DOI: 10.7508/ibj.2015.04.006
PMID: 26239213
PMCID: PMC4649858


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zamani Z, Zare S, Sadrkhanlou R, Ahmadi A, Movahed E. Chlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus. IBJ. 2015; 19 (4) :226-232
URL: http://ibj.pasteur.ac.ir/article-1-1485-en.html
Volume 19, Issue 4 (10-2015) Back to browse issues page
Persian site map - English site map - Created in 0.147 seconds with 878 queries by yektaweb 3567