Volume 19, Issue 4 (10-2015)                   ibj 2015, 19(4): 247-253 | Back to browse issues page

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Khalatbary A R, Ghaffari E, Mohammadnegad B. Protective Role of Oleuropein against Acute Deltamethrin- Induced Neurotoxicity in Rat Brain. ibj. 2015; 19 (4) :247-253
URL: http://ibj.pasteur.ac.ir/article-1-1471-en.html

Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment. Results: The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treated-mice compared with DM group. Conclusion: The results suggested that DM-induced neurotoxicity can be subsided by OE.

Type of Study: Short Communication | Subject: Related Fields

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