Volume 17, Issue 4 (10-2013)                   IBJ 2013, 17(4): 214-220 | Back to browse issues page

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Abdanipour A, Tiraihi T, Taheri T, Kazemi H. Microglial Activation in Rat Experimental Spinal Cord Injury Model. IBJ 2013; 17 (4) :214-220
URL: http://ibj.pasteur.ac.ir/article-1-1025-en.html
Background: The present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (SCI). Methods: A quantitative histological study was performed to determine ED-1 positive cells, glial cell density, and cavitation size in untreated SCI rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. Results: The results of glial cell quantification along the 4900-µm long injured spinal cord showed a significant increase in glial cell density percentage at day 2 as compared to other days. Whereas the highest increase in ED-1 immunoreactive cells (monocyte/phagocyte marker in rats) was observed at day 2 (23.15%) post-injury. Evaluation of cavity percentage showed a significant difference between weeks 3 and 4 post-injury groups. Conclusions: This study provides a new insight into the multiphase immune response to SCI, including cellular inflammation, macrophages/microglia activation, glial cell density, and cavitation. Better understanding of the inflammatory processes associated with acute SCI would permit the development of better therapeutic strategies.
Type of Study: Full Length/Original Article | Subject: Related Fields

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