Volume 28, Issue 2 (3-2024)                   IBJ 2024, 28(2): 7-7 | Back to browse issues page

Ethics code: IR.SBMU.RETECH.REC.1397.478


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Jahi H, Eslami M, Sayyah* M, Karimzadeh F, Alesheikh M. Curcumin Lowers the Accelerated Speed of Epileptogenesis by Traumatic Brain Injury. IBJ 2024; 28 (2) :7-7
URL: http://ibj.pasteur.ac.ir/article-1-3976-en.html
Abstract:  
Background: Traumatic brain injury or TBI can underlie epilepsy. Prevention of PTE has been of great interest to scientists. Given the antiepileptic, antioxidant and anti-inflammatory activities of curcumin, we examined whether this compound can affect epileptogenesis in rats after TBI.
Methods Curcumin was injected once a day for two weeks. TBI was induced in the temporal cortex of anesthetized rats using a CCI device. One day after TBI, PTZ, 35 mg/kg, was injected i.p. every other day until manifestation of generalized seizures. The number of PTZ injections was then recorded. Moreover, the extent of cortical and hippocampal IL-1β and GFAP expression in the epileptic rats were measured by Western blot analysis.
Results: Curcumin 50 and 150 mg/kg prevented the development of kindling, wherase TBI accelerated the rate of kindling. Curcumin 20 mg/kg prohibited kindling facilitation by TBI, and reduced the expression of IL-1β and GFAP induced by TBI.
Conclusion: Curcumin can stop the acceleration of epileptogenesis after TBI in rats. Inhibiting hippocampal and cortical overexpression of IL-1β and GFAP seems to be involved in this activity.

 
Type of Study: Full Length/Original Article | Subject: Related Fields

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