Iranian Biomedical Journal

en Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review Molecular Microbiology Molecular Microbiology مقاله کامل Full Length/Original Article Vaccines, Chronic obstructive pulmonary disease, Haemophilus influenzae 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-644&slc_lang=en&sid=1 Ava No

other Related Fields Related Fields کنگره Congress 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-937&slc_lang=other&sid=1

other Related Fields Related Fields مقاله کامل Full Length/Original Article <img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" > 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6564-3&slc_lang=other&sid=1

other Global Perspectives on Rabies Prevention and Control: A Decade of World Rabies Day Themes and Progress toward Elimination (2016–2025) Related Fields Related Fields دیدگاهی-مروری Perspective Review <img alt="" src="./files/site1/images/Copy_editing.png" > 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6347-2&slc_lang=other&sid=1 A Alamdary No M Ajorloo No Alireza Gholami Yes

en Effects of Peptides and Bioactive Peptides on Acute Kidney Injury: A Review Study Related Fields Related Fields مقاله مروری Review Article Acute kidney injury, Bioactive peptides, Cisplatin, Ischemia, Reperfusionreperfusion. 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-1&slc_lang=en&sid=1 Zeynab Mohamadi Yarijani zeynab_mohamadi95@yahoo.com 0000-0002-0693-6788 No Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Houshang Najafi houshang.najafi@gmail.com 0000-0001-9642-9124 Yes Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

en Combined Role of Growth Differentiation Factor 15 and Oxidative Stress Markers in Hemoglobin H Disease: A Genotype-Based Insight Molecular Genetics & Genomics Molecular Genetics & Genomics مقاله کامل Full Length/Original Article <img alt="" src="./files/site1/images/Copy_editing.png" > Hemoglobin H disease, GDF-15, Oxidative stress, Malondialdehyde, α-globin genotype, Thalassemia, Transfusion dependency 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1166-3&slc_lang=en&sid=1 Elaheh Saniei elahetisaniei@uomustansiriyah.edu.iq No Department of chemistry and biochemistry, college of medicine, Mustansiriyah University, Baghdad, Iraq Abdulkareem H. Issa issa.abdulkareem@uomustansiriyah.edu.iq No Department of chemistry and biochemistry, college of medicine, Mustansiriyah University, Baghdad, Iraq Azita Azarkeivan azazarkeivan@yahoo.com No Iranian Blood Transfusion Organization (IBTO), High Institute for Research and Education in Transfusion Medicine, Thalassemia Clinic, Tehran, Iran Hassan Abolghasemi H.abolghasemi.ha@gmail.com No Department of pediatrics, Baqiyatallah University of Medical Sciences, Tehran, Iran Morteza Karimipoor mortezakarimi@yahoo.com Yes Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

en Resveratrol in Combination Therapy: Mechanisms and Limitations of Resveratrol in Cancer, Regeneration, and Chronic Disease Tissue Engineering and Cell Biology Tissue Engineering and Cell Biology مقاله مروری Review Article RSV, Biological activity, Nanoparticles, Regenerative medicine 0 0 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6430-1&slc_lang=en&sid=1 effat noori effat.noori@yahoo.com No Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran Ramazan Rezaei R.rezaei@shahed.ac.ir No Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran Samira Valiyari samiravaliyari@yahoo.com No Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran Mahmood Rekabgardan m.rekabgardan@gmail.com No Department of Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Parvin Mohammadi pmohammadi069@gmail.com No Department of Medical Biotechnology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Fatemeh Soleymani fatemeh.soleymani20300@gmail.com No Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran Elham Sharif elhamsharifpharmd@gmail.com No Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Zohreh Jafari Zohrehjafari2021@gmail.com No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Delsuz Rezaee rezaeedelsuz@yahoo.com No Department of Genetic and Molecular Medicine, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran Fatemeh Hajighasemi fatimahajighasemi@gmail.com No Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran Forough Shams Forough.shamss@gmail.com Yes Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 7 7 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-2&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 8 8 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-4&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 8 8 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-3&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 9 9 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-6&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 9 9 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-5&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 10 10 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-7&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 11 11 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-8&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 12 12 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-9&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 13 13 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-10&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 14 14 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-11&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 15 15 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-12&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 16 16 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-13&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 17 17 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-14&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 18 18 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-15&slc_lang=other&sid=1

other Related Fields Related Fields مقاله مروری Review Article Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model. Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR. Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways. Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.   <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> 19 19 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6156-16&slc_lang=other&sid=1