en مقاله کامل Full Length/Original Article Elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. Therefore, we made attempts to investigate the protective effect of vitamin E (vit-E), a biological antioxidant in BALB/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. Several groups of mice were selected and exposed to sub-lethal g -irradiation with or without vit-E supplementation. At the end of exposure, mice were immunized by either live attenuated Brucellamelitensis vaccine or sheep red blood cell (SRBC). Consequently, the following parameters were assayed: specific antibody response, delayed type hypersensitivity and lymphocyte proliferation. We showed that vit-E supplementation restored the immune response in g -irradiated mice. These findings might have implications for individuals who are at risk of exposure to ionizing radiation. Vitamin E, Immune response, γ -Irradiation, BALB/c mice 51 55 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-429&slc_lang=en&sid=1 Sussan K. Ardestani سوسن کبودیان اردستانی ibbsks@ibb.uc.ir Yes Mogtaba Amani مجتبی امانی No Amina kariminia آمینا کریمی نیا No