Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1378
10
1
gregorian
2000
1
1
4
1
online
1
fulltext
en
Prevention of Experimental Autoimmune Vitiligo by Oral Administration of Mushroom Tyrosinase
مقاله کامل
Full Length/Original Article
Experimental autoimmune vitiligo was induced by the intradermal injection of the purified mushroom tyrosinase emulsified in Complete Freund’s Adjuvant (CFA) in female C57BL/6 mice. The onset of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. Oral administration of semipurified mushroom tyrosinase prevented experimental autoimmune vitiligo (EAV). Suppression of clinical and histological disease was observed when animals received mushroom tyrosinase. A decrease in lymphocyte proliferation, delayed type hypersensitivity responses, increase in humoral immunity of the mice may all suggest that the suppression of the disease is correlated with cellular immune responses suppression. Based on our data, it may be concluded that the oral administration of the mushroom tyrosinase may have practical implications in vitiligo.
Mushroom tyrosinase, Experimental autoimmune vitiligo, Oral tolerance
31
36
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-399&slc_lang=en&sid=1
Tahere
Zehtab
طاهره
زهتاب
100319475328460057940
100319475328460057940
No
Razieh
Yazdanparast
راضیه
یزدان پرست
100319475328460057941
100319475328460057941
Yes
Shahnaz
Rafieii
شهناز
رفیعی
100319475328460057942
100319475328460057942
No