Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1387
4
1
gregorian
2008
7
1
12
3
online
1
fulltext
en
Beta Cell Protective Effects of Sodium Tungstate in Streptozotocin-Induced Diabetic Rats: Glycemic Control, Blockage of Oxidative Stress and Beta Cell Histochemistry
Beta Cell Protective Effects of Sodium Tungstate in Streptozotocin-Induced Diabetic Rats: Glycemic Control, Blockage of Oxidative Stress and Beta Cell Histochemistry
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic rats from one week before STZ injection (TDB), food-restricted diabetic (FRD), tungstate treated control, sodium tungstate treated diabetic rats from one week after STZ administration (TDA). We evaluated serum insulin, glucose and glucose tolerance liver glycogen content, glucokinase (GK) activity blood and pancreas antioxidant power, lipid peroxidation and fuchsin-aldehyde histochemical staining of beta-cells. Results: Blood glucose levels of TDB group were lower than other diabetic groups (P<0.01). Blood insulin levels of all diabetic groups were lower than controls (P<0.01). Glucose intolerance improved in TDB animals. Blood and pancreas antioxidant power, liver glycogen contents and GK activities and granulated beta cells increased in TDB rats in comparison with other diabetic groups (P<0.01). Likewise, lipid peroxidation decreased significantly in TDB rats (P<0.01). Conclusions: Results suggested that sodium tungstate if administrated before STZ injection improves glycemic state by a direct effect on pancreatic beta-cells and preserves them by reducing the activity of these cells at the time of STZ injection, reducing STZ-induced oxidative stress, reducing insulin secretion, or all of the above mentioned.
Diabetes mellitus, Sodium tungstate, Beta cells
143
152
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-48&slc_lang=en&sid=1
Zahra
Heidari
زهرا
حیدری
histology_iri@yahoo.com
100319475328460056985
100319475328460056985
Yes
Mehdi
Harati
مهدی
هراتی
100319475328460056986
100319475328460056986
No
Hamid Reza
Mahmoudzadeh-Sagheb
حمیدرضا
محمودزاده ثاقب
100319475328460056987
100319475328460056987
No
Bita
Moudi
بیتا
مودی
100319475328460056988
100319475328460056988
No