Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1378
12
1
gregorian
2000
3
1
4
2
online
1
fulltext
en
Effects of Dietary Chitosan on Serum Lipid and Lipoprotein Concentration in Rats
مقاله کامل
Full Length/Original Article
Because the ingestion of some types of dietary fibers has been shown to influence on the lipid and lipoprotein levels, it is possible that chitosan influences on lipid metabolism. In the present study, the effects of chitosan on the serum, liver lipid and lipoprotein concentrations in rat were investigated. Serum lipid level in the treatment groups were decreased compared to that of the control, cholesterol level [128.65 +/- 2.58 (mean +/- SD, n = 72) vs. 173.67 +/- 3.62, p<0.05] mg/dl, triglyceride level [62.83 +/- 2.73 (mean +/- SD) vs. 93.62 +/- 2.64, p<0.05] mg/dl, and low density lipoprotein-cholesterol level [108.35 +/- 2.41(mean +/- SD) vs. 156.49 +/- 2.37, p<0.05] mg/dl. In the chitosan treatment group, high density lipoprotein-cholesterol level was increased as compared to the control [187.39 +/- 2.74 (mean +/- SD) vs. 163.54 +/- 2.83, p<0.05] mg/dl. This work showed that the addition of chitosan to the diet of the rats significantly lowered the liver lipid in the treatment groups compared to that of the control, cholesterol level [31.53 +/- 1.26(mean +/- SD) vs. 64.42 +/- 2.38, p<0.05] mg/g, and triglyceride level [38.46 +/- 2.64 (mean +/- SD) vs. 53.24 +/- 2.45, p<0.05] mg/g. When chitosan fed at the 5% level, concentration of the serum cholesterol was reduced by 25.92% and triglyceride by 32.89%. The data presented here indicated possible usefulness of chitosan for the treatment of hyperlipidemia.
Chitosan, Cholesterol, Lipoprotein
69
73
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-392&slc_lang=en&sid=1
Durdi
Qujeq
دوردی
قوجق
100319475328460057928
100319475328460057928
Yes
Gholamreza
Ataei
غلامرضا
عطایی
100319475328460057929
100319475328460057929
No