Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1391
10
1
gregorian
2013
1
1
17
1
online
1
fulltext
en
کمبود ویتامین D یادگیری فضایی در موشهای صحرایی بالغ را کاهش می دهد
Vitamin D Deficiency Impairs Spatial Learning in Adult Rats
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Through its membrane and intracellular receptors, vitamin D regulates many vital functions in the body including its well known actions on musculoskeletal system. Growing body of evidences demonstrate that vitamin D undergoes some of behavioral aspects of neurocognition. The present study was designed to evaluate the effect of food regimens without vitamin D or with a supplement of 1,25(OH)2D3 on spatial performance of adult rats. Methods: The animals were trained in the Morris water maze to find a hidden platform. The time spent and the distance travelled to find the platform, speed of navigation and the percentage of unsuccessful trials were considered for assessment of the task learning. Results: Our findings indicated that the vitamin D-deprived rats had a significant lower performance compared to both the controls and the animals receiving 1,25(OH)2D3 supplementation. Concerning the unsuccessful trials, lack of vitamin D resulted in the highest failures in the maze navigation. The regimen with additional 1,25(OH)2D3 did not considerably influence learning of the maze task. Conclusion: We concluded that while vitamin D deficiency deteriorates the spatial task learning, the 1,25(OH)2D3 supplementation did not effectively underlie the maze performance.
Vitamin D, Maze learning, Dietary supplements
42
48
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-376&slc_lang=en&sid=1
Mohsen
Taghizadeh
محسن
تقی زاده
100319475328460056388
100319475328460056388
No
Sayyed Alireza
Talaei
سید علیرضا
طلایی
100319475328460056389
100319475328460056389
No
Mahmoud
Salami
محمود
سلامی
salami-m@kaums.ac.ir
100319475328460056390
100319475328460056390
Yes