Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
-
en
jalali
1391
4
1
gregorian
2012
7
1
16
3
online
1
fulltext
en
ترکیب اسیدهای چرب فسفولیپیدهای مایع فولیکولی انسانی و میزان باروری در روش های کمک باروری
Fatty Acid Composition of Human Follicular Fluid Phospholipids and Fertilization Rate in Assisted Reproductive Techniques
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women’s fertility and the efficacy of assisted reproduction techniques. The aim of this study was to investigate the effect of fatty acid composition of follicular fluid phospholipids on women undergoing assisted reproductive techniques. Methods: Follicular fluid samples were obtained from 100 patients, referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent in vitro fertilization (IVF) and the remaining 21 underwent intracytoplasmic sperm injection (ICSI). Total lipid of follicular fluid was extracted and fatty acids were analyzed by gas-liquid chromatography. Results: Saturated fatty acids (SFA, P = 0.002) and the ratio of SFA to polyunsaturated fatty acids (P = 0.001) were correlated negatively with a number of mature oocytes after age adjustment. Linoleic acid (P = 0.006) was positively correlated, while the level of arachidonic acid was negatively correlated with fertility percentage after adjustment for body mass index, sperm count, sperm motility. Conclusion: Since phospholipids are one of the major components of lipid metabolism, the results of this study highlight the importance of this component in follicular fluid lipid metabolism. Consequently, it is proposed as an index in determination of the rate of success in assisted reproductive techniques such as IVF/ICSI.
Follicular fluid, Fatty acids, Assisted reproductive techniques
168
162
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-364&slc_lang=en&sid=1
Maghsod
Shaaker
مقصود
شاکر
100319475328460056483
100319475328460056483
No
Ali
Rahimipour
علی
رحیمی پور
100319475328460056484
100319475328460056484
No
Mohammad
Nouri
محمد
نوری
100319475328460056485
100319475328460056485
No
Korosh
Khanaki
کوروش
خانکی
100319475328460056486
100319475328460056486
No
Masoud
Darabi
مسعود
دارابی
100319475328460056487
100319475328460056487
No
Laya
Farzadi
لعیا
فرزدی
100319475328460056488
100319475328460056488
No
Vahideh
Shahnazi
وحیده
شهنازی
100319475328460056489
100319475328460056489
No
Amir
Mehdizadeh
امیر
مهدی زاده
a.mehdizadeh@hotmail.com
100319475328460056490
100319475328460056490
Yes