en Synthesis and Application of New Gadolinium-Porphyrins as Potential MR Imaging Contrast Agents for Cancer Detection in Nude Mice مقاله کامل Full Length/Original Article Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed in human melanoma tumors grafted in the nude mice 24 h after injection of Gd-TCP and Gd-H, respectively. The percent of injected Gd, that localized to the tumor and measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES), was approximately 21% for Gd-TCP and 28% for Gd-H. A higher concentration of Gd was achieved compared with control indicating selective delivery of Gd-porphyrins to the melanoma xenografts. The data indicate that Gd-TCP can be used as a dual probe for diagnosis in MR imaging and for therapy in boron neutron capture therapy (BNCT). MR imaging, Contrast agent, Porphyrins, Melanoma, Cancer 87 95 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-345&slc_lang=en&sid=1 Daryoush Shahbazi-Gahrouei داریوش شهبازی گهرویی shahbazi24@yahoo.com Yes Mark Williams Barry J. Allen No Barry J. Allen Mark Williams No