Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
-
en
jalali
1379
12
1
gregorian
2001
3
1
5
2
online
1
fulltext
en
Up-Regulation of Integrinsα2β1 and α3β1 Expression in Human Foreskin Fibroblast Cells after In-Vitro Infection with Herpes Simplex Virus Type 1
Up-Regulation of Integrinsn α2β1 and α3β1 Expression in Human Foreskin Fibroblast Cells after In-Vitro Infection with Herpes Simplex Virus Type 1
مقاله کامل
Full Length/Original Article
The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1, α3β1 (a collagen and laminin receptor) and LFA-1 (a β2 integrin, ligand for intercellular adhesion molecule-1, ICAM-1) integrins without a significant change in the expression of α5b1 (a fibronectin receptor) as compared to the mock-challenged cells. In addition, virus challenged HFFF cells showed increased expression of ICAM-1 and HLA class I antigen when compared to mock-infected cells. These results suggest that HSV-1 is capable of inducing functional changes in human foreskin fibroblast cells. The altered expression of cell-matrix and cell-cell adhesion molecules resulting from HSV-1 infection could contribute to the immunopathological diseases associated with HSV-1 infection in vivo.
Fibroblasts, HSV-1, Integrin receptors, Adhesion molecules
55
59
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-344&slc_lang=en&sid=1
Shapour
Shahgasempour
شاپور
شاه قاسم پور
100319475328460057852
100319475328460057852
Yes
Ali
Shamsi Shahomabadi
علی
شمسی شهرآبادی
100319475328460057853
100319475328460057853
No
Farah-Dokht
Fateminasab
فرح دخت
فاطمی نسب
100319475328460057854
100319475328460057854
No
Abbas
Barin
عباس
برین
100319475328460057855
100319475328460057855
No