en Antiepileptic Potential and Composition of the Fruit Essential Oil of Ferula Gummosaboiss مقاله کامل Full Length/Original Article The fruit essential oil of Ferula gummosa boiss., Umbelliferae, which has been used as an antiepileptic remedy in Iranian traditional medicine, was evaluated for anticonvulsant activity against experimental seizures. The essential oil had no effect against seizures induced by maximal electroshock. However, it protected mice against pentylenetetrazole-induced tonic seizures. The protective dose produced neurotoxicity. Moreover, this dose was too close to the LD50 of the essential oil. Gas chromatography and gas chromatography-mass spectroscopy analyses of the essential oil revealed the presence of alpha-pinene (50.1%), alpha-pinene (18.3%), 3-carene (6.7%), alpha-thujene (3.3%) and sabinene (3.1%) as the main components. The anticonvulsant and toxic effects of the essential oil may be related to the compounds pinene and alpha-thujene respectively that present in the essential oil. Constituents, Essential oil, Ferula gummosa, Seizure protection 69 72 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-343&slc_lang=en&sid=1 Mohammad Sayyah محمد سیاح sayyah@pasteur.ac.ir Yes Mohammad Kamalinejad محمد کمالی نژاد No Rajab Bahrami Hidage رجب بهرامی هیدج No Abdolhossein Rustaiyan عبدالحسین روستاییان No