Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1379
12
1
gregorian
2001
3
1
5
2
online
1
fulltext
en
Antiepileptic Potential and Composition of the Fruit Essential Oil of Ferula Gummosaboiss
Antiepileptic Potential and Composition of the Fruit Essential Oil of Ferula Gummosa boiss
مقاله کامل
Full Length/Original Article
The fruit essential oil of Ferula gummosa boiss., Umbelliferae, which has been used as an antiepileptic remedy in Iranian traditional medicine, was evaluated for anticonvulsant activity against experimental seizures. The essential oil had no effect against seizures induced by maximal electroshock. However, it protected mice against pentylenetetrazole-induced tonic seizures. The protective dose produced neurotoxicity. Moreover, this dose was too close to the LD50 of the essential oil. Gas chromatography and gas chromatography-mass spectroscopy analyses of the essential oil revealed the presence of alpha-pinene (50.1%), alpha-pinene (18.3%), 3-carene (6.7%), alpha-thujene (3.3%) and sabinene (3.1%) as the main components. The anticonvulsant and toxic effects of the essential oil may be related to the compounds pinene and alpha-thujene respectively that present in the essential oil.
Constituents, Essential oil, Ferula gummosa, Seizure protection
69
72
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-343&slc_lang=en&sid=1
Mohammad
Sayyah
محمد
سیاح
sayyah@pasteur.ac.ir
100319475328460057860
100319475328460057860
Yes
Mohammad
Kamalinejad
محمد
کمالی نژاد
100319475328460057861
100319475328460057861
No
Rajab
Bahrami Hidage
رجب
بهرامی هیدج
100319475328460057862
100319475328460057862
No
Abdolhossein
Rustaiyan
عبدالحسین
روستاییان
100319475328460057863
100319475328460057863
No